![]() In general, each BB agent slightly differs in their membrane stabilizing activity, lipophilicity, and selectivity. It also means they are more amenable to lipid emulsion therapy. This allows them to rapidly cross the blood-brain barrier. Some BB possess high lipid solubility (e.g. Receptor activation = lipolysis.Īll BB antagonize the beta receptor on the cell surface, decreasing cAMP. ![]() Receptor activation = bronchodilation and vasodilation.īeta-3 : adipose tissue and heart. Receptor activation = increased inotropy, chronotropy, and AV conduction.īeta-2 : bronchial smooth muscle and peripheral smooth vascular muscle. However, remember at toxic doses selectivity is lost & BB antagonize all 3 types.īeta-1 : heart muscle. BB can be selective (Beta-1, like metoprolol) for some of these or are nonspecific, like carvedilol or propranolol. Propranolol was the most common BB overdose.īeta receptors are sympathomimetic receptors found throughout the body. The vast majority of cases are unintentional (~80%), and 10% of total cases were deemed as moderate-major outcomes. Millions of Americans are on these medications, and although they are very well-tolerated, toxicity is associated with substantial morbidity and mortality. Peer Reviewers: Travis Smith, DO, Sean O’Sullivan, MDīeta-blockers (BB) have a long history of treating a variety of diseases. Want to experience the greatest in board studying? Check out our interactive question bank podcast- the FIRST of its kind here:
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